Many hands make light work

Many hands make light work.

Synaptogenic Proteins and Synaptic Organizers: “Many Hands Make Light Work”

Synaptogenesis is thought to be mediated by cell adhesion proteins, which induce the initial contact between an axon and its target cell and subsequently recruit and organize the presynaptic and postsynaptic protein machinery required for synaptic transmission. A new study by Linhoff and colleagues in this issue of Neuron identifies adhesion proteins of the LRRTM family as novel synaptic organi...

Many Hands Make Light Work: Further Studies in Group Evolution

When niching or speciation is required to perform a task that has several different component parts, standard genetic algorithms (GAs) struggle. They tend to evaluate and select all individuals on the same part of the task, which leads to genetic convergence within the population. The goal of evolutionary niching methods is to enforce diversity in the population so that this genetic convergence...

Many ABCs make light work with cholesterol

recognition. The key role of cholesterol metabolism in cardiovascular diseases has been accepted long ago; emerging evidence now supports the central role of cholesterol metabolism in neurodegenerative, metabolic, skin and infectious diseases. Cellular cholesterol content has to be maintained within tight limits, or else; not surprisingly, therefore, a number of regulatory mechanisms provide mu...

Distributed computing and data storage in proteomics: many hands make light work, and a stronger memory.

Modern day proteomics generates ever more complex data, causing the requirements on the storage and processing of such data to outgrow the capacity of most desktop computers. To cope with the increased computational demands, distributed architectures have gained substantial popularity in the recent years. In this review, we provide an overview of the current techniques for distributed computing...